| 1. Round | 18/02/2012 | Montevideo Wanderers | - | Danubio | 1:1 | ||||
| 4. Round | 11/03/2012 | Danubio | - | Rampla Juniors | 3:2 | ||||
| 6. Round | 01/04/2012 | Danubio | - | Peñarol | 3:2 | ||||
| 8. Round | 15/04/2012 | Danubio | - | El Tanque Sisley | 2:1 |  |
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| 9. Round | 21/04/2012 | Racing | - | Danubio | 0:1 | ||||
| 10. Round | 28/04/2012 | Danubio | - | Liverpool | 0:0 | ||||
| 11. Round | 06/05/2012 | Danubio | - | Defensor Sporting | 0:1 | ||||
| 12. Round | 13/05/2012 | River Plate | - | Danubio | 1:1 | ||||
| 13. Round | 19/05/2012 | CA Cerro | - | Danubio | 1:2 | ||||
| 14. Round | 27/05/2012 | Danubio | - | Cerro Largo | 1:1 |
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