| 1. Round | 01/06/2021 | Albion | - | CA Cerro | 1:2 | ||||
| 4. Round | 25/06/2021 | Uruguay Montevideo | - | Albion | 2:2 | ||||
| 5. Round | 30/06/2021 | Albion | - | Central Español | 1:2 | ||||
| 6. Round | 08/07/2021 | Rampla Juniors | - | Albion | 0:1 |  |
|||
| 7. Round | 15/07/2021 | Albion | - | Atenas | 1:0 | ||||
| 8. Round | 22/07/2021 | Danubio | - | Albion | 0:2 | ||||
| 9. Round | 29/07/2021 | Albion | - | Racing | 0:0 | |
|||
| 10. Round | 04/08/2021 | Rocha | - | Albion | 0:2 | ||||
| 11. Round | 14/08/2021 | Albion | - | Villa Teresa | 2:0 | ||||
| 12. Round | 17/09/2021 | CA Cerro | - | Albion | 1:0 | ||||
| 13. Round | 22/09/2021 | Albion | - | Juventud de Las Piedras | 1:0 | |
|||
| 16. Round | 11/10/2021 | Central Español | - | Albion | 3:4 | |
|||
| 18. Round | 28/10/2021 | Atenas | - | Albion | 1:2 | ||||
| 19. Round | 01/11/2021 | Albion | - | Danubio | 2:1 | ||||
| 22. Round | 24/11/2021 | Villa Teresa | - | Albion | 1:1 |
Uruguay