2. Round | 18/09/2021 | Villa Española | - | Sud América | 1:2 | ||||
3. Round | 24/09/2021 | Plaza Colonia | - | Villa Española | 4:0 | ||||
4. Round | 02/10/2021 | Villa Española | - | Fénix | 1:2 | ||||
5. Round | 10/10/2021 | Boston River | - | Villa Española | 1:0 | ||||
6. Round | 17/10/2021 | Villa Española | - | Montevideo Wanderers | 2:2 | ||||
7. Round | 20/10/2021 | Rentistas | - | Villa Española | 3:1 | ||||
8. Round | 23/10/2021 | Villa Española | - | Peñarol | 1:3 | ||||
14. Round | 30/11/2021 | River Plate | - | Villa Española | 4:2 |