| 1. Round | 10/07/2022 | Macará | - | Emelec | 1:3 | ||||
| 2. Round | 16/07/2022 | Orense SC | - | Macará | 1:1 | ||||
| 3. Round | 26/07/2022 | Macará | - | Delfín SC | 1:2 | ||||
| 4. Round | 31/07/2022 | Macará | - | Universidad Catolica | 1:3 | ||||
| 5. Round | 06/08/2022 | Guayaquil City | - | Macará | 0:0 | ||||
| 6. Round | 14/08/2022 | Cumbayá | - | Macará | 1:0 | ||||
| 7. Round | 21/08/2022 | Macará | - | Aucas | 1:1 |  |
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| 8. Round | 27/08/2022 | Deportivo Cuenca | - | Macará | 1:1 |  |
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| 9. Round | 04/09/2022 | Macará | - | Mushuc Runa | 3:0 | |
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| 10. Round | 11/09/2022 | Barcelona | - | Macará | 5:3 | ||||
| 11. Round | 17/09/2022 | Macará | - | Gualaceo SC | 1:1 | |
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| 12. Round | 25/09/2022 | Independiente del Valle | - | Macará | 1:0 | ||||
| 15. Round | 22/10/2022 | Macará | - | LDU Quito | 0:5 |
Uruguay