| 1. Round | 05/02/2017 | Plaza Colonia | - | Boston River | 0:0 | ||||
| 2. Round | 12/02/2017 | Boston River | - | River Plate | 2:0 |  |
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| 6. Round | 12/03/2017 | Boston River | - | Liverpool | 3:1 |  |
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| 7. Round | 18/03/2017 | CA Cerro | - | Boston River | 2:0 | ||||
| 8. Round | 25/03/2017 | Montevideo Wanderers | - | Boston River | 2:1 | ||||
| 9. Round | 01/04/2017 | Boston River | - | Nacional | 3:1 | ||||
| 10. Round | 08/04/2017 | Fénix | - | Boston River | 1:2 | |
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| 11. Round | 16/04/2017 | Boston River | - | Rampla Juniors | 4:0 | |
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| 12. Round | 23/04/2017 | Defensor Sporting | - | Boston River | 1:0 | ||||
| 13. Round | 29/04/2017 | Boston River | - | Sud América | 1:0 | |
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| 14. Round | 07/05/2017 | Juventud de Las Piedras | - | Boston River | 2:5 | |
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| 15. Round | 14/05/2017 | Boston River | - | Danubio | 0:3 |
Uruguay