| 1. Round | 03/06/2021 | Nacional | - | Cerro Largo | 1:2 |  |
|||
| 9. Round | 03/07/2021 | Cerro Largo | - | Fénix | 1:2 |  |
|||
| 10. Round | 11/07/2021 | Boston River | - | Cerro Largo | 1:0 | |
|||
| 11. Round | 17/07/2021 | Cerro Largo | - | Montevideo Wanderers | 2:0 | ||||
| 12. Round | 30/07/2021 | Rentistas | - | Cerro Largo | 1:3 | ||||
| 13. Round | 06/08/2021 | Cerro Largo | - | Peñarol | 0:1 | ||||
| 14. Round | 15/08/2021 | Montevideo City Torque | - | Cerro Largo | 3:0 |
Uruguay