| 1. Round | 06/02/2022 | Boston River | - | Plaza Colonia | 0:0 | ||||
| 2. Round | 13/02/2022 | Boston River | - | Cerrito | 0:1 | ||||
| 9. Round | 15/04/2022 | Danubio | - | Boston River | 0:0 |  |
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| 10. Round | 24/04/2022 | Boston River | - | Deportivo Maldonado | 2:0 | ||||
| 11. Round | 08/05/2022 | Rentistas | - | Boston River | 0:1 | ||||
| 12. Round | 16/05/2022 | Boston River | - | Liverpool | 2:3 | ||||
| 13. Round | 21/05/2022 | Peñarol | - | Boston River | 1:0 | |
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| 14. Round | 28/05/2022 | Boston River | - | Montevideo City Torque | 3:1 | ||||
| 15. Round | 06/06/2022 | Montevideo Wanderers | - | Boston River | 1:2 |
Uruguay