| 1. Round | 21/07/2018 | Boston River | - | River Plate | 2:3 |  |
|||
| 2. Round | 29/07/2018 | River Plate | - | Peñarol | 0:1 | |
|||
| 3. Round | 04/08/2018 | Atenas | - | River Plate | 1:1 | |
|||
| 4. Round | 12/08/2018 | River Plate | - | Danubio | 1:2 | ||||
| 5. Round | 19/08/2018 | Torque | - | River Plate | 3:0 | ||||
| 6. Round | 26/08/2018 | River Plate | - | Rampla Juniors | 3:4 | ||||
| 7. Round | 01/09/2018 | Fénix | - | River Plate | 1:3 | |
|||
| 12. Round | 14/10/2018 | CA Cerro | - | River Plate | 4:2 | ||||
| 14. Round | 28/10/2018 | Liverpool | - | River Plate | 4:1 | |
Uruguay