| 1. Round | 30/04/2022 | Villa Española | - | Rampla Juniors | 3:2 | ||||
| 2. Round | 08/05/2022 | Rampla Juniors | - | Juventud de Las Piedras | 0:1 |  |
|||
| 3. Round | 15/05/2022 | Racing | - | Rampla Juniors | 1:0 | ||||
| 8. Round | 12/06/2022 | CA Cerro | - | Rampla Juniors | 1:0 | |
|||
| 9. Round | 18/06/2022 | Rampla Juniors | - | Sud América | 0:0 | ||||
| 10. Round | 23/06/2022 | Central Español | - | Rampla Juniors | 2:0 | |
|||
| 11. Round | 26/06/2022 | Rampla Juniors | - | Miramar Misiones | 1:2 | |
|||
| 12. Round | 24/07/2022 | Rampla Juniors | - | Villa Española | 1:0 | ||||
| 13. Round | 31/07/2022 | Juventud de Las Piedras | - | Rampla Juniors | 1:2 | ||||
| 14. Round | 07/08/2022 | Rampla Juniors | - | Racing | 1:0 | ||||
| 15. Round | 13/08/2022 | Uruguay Montevideo | - | Rampla Juniors | 0:4 | ||||
| 16. Round | 20/08/2022 | Progreso | - | Rampla Juniors | 0:1 | ||||
| 17. Round | 23/08/2022 | Rampla Juniors | - | La Luz | 0:3 | |
|||
| 19. Round | 03/09/2022 | Rampla Juniors | - | CA Cerro | 2:2 | ||||
| 20. Round | 11/09/2022 | Sud América | - | Rampla Juniors | 2:1 |  |
|||
| 22. Round | 25/09/2022 | Miramar Misiones | - | Rampla Juniors | 1:3 |
Uruguay