| 1. Round | 07/08/2021 | RFCU Luxemburg | - | Swift Hesperange | 0:3 |  |
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| 2. Round | 14/08/2021 | FC Rodange 91 | - | RFCU Luxemburg | 0:1 | ||||
| 3. Round | 21/08/2021 | RFCU Luxemburg | - | RM Hamm Benfica | 1:0 | |
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| 4. Round | 28/08/2021 | FC Wiltz 71 | - | RFCU Luxemburg | 2:3 | ||||
| 6. Round | 18/09/2021 | Jeunesse Esch | - | RFCU Luxemburg | 0:2 | ||||
| 7. Round | 22/09/2021 | RFCU Luxemburg | - | US Hostert | 7:0 | ||||
| 8. Round | 26/09/2021 | Progrès Niedercorn | - | RFCU Luxemburg | 0:2 | |
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| 10. Round | 23/10/2021 | RFCU Luxemburg | - | US Mondorf | 2:1 | ||||
| 12. Round | 21/11/2021 | RFCU Luxemburg | - | FC Differdange 03 | 3:1 | ||||
| 13. Round | 28/11/2021 | Victoria Rosport | - | RFCU Luxemburg | 3:1 | |
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| 14. Round | 04/12/2021 | RFCU Luxemburg | - | CS FOLA Esch | 0:1 | ||||
| 15. Round | 11/12/2021 | UNA Strassen | - | RFCU Luxemburg | 3:0 |
Luxembourg
Algeria