| 1. Round | 17/07/2021 | Aldosivi | - | Patronato de Paraná | 0:2 | ||||
| 2. Round | 24/07/2021 | Platense | - | Aldosivi | 0:1 | ||||
| 3. Round | 27/07/2021 | Aldosivi | - | Racing Club | 0:2 | ||||
| 4. Round | 02/08/2021 | Rosario Central | - | Aldosivi | 1:2 | ||||
| 5. Round | 09/08/2021 | Aldosivi | - | Defensa y Justicia | 1:0 | ||||
| 6. Round | 14/08/2021 | Atlético Tucumán | - | Aldosivi | 2:2 | ||||
| 7. Round | 20/08/2021 | Aldosivi | - | Colón de Santa Fe | 3:0 | ||||
| 8. Round | 27/08/2021 | River Plate | - | Aldosivi | 2:0 | ||||
| 9. Round | 29/08/2021 | Aldosivi | - | Lanús | 2:3 |  |
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| 10. Round | 04/09/2021 | Huracán | - | Aldosivi | 2:0 | ||||
| 11. Round | 13/09/2021 | Aldosivi | - | Godoy Cruz | 1:4 | ||||
| 12. Round | 18/09/2021 | Vélez Sarsfield | - | Aldosivi | 3:2 |
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