| 6. Round | 24/07/2022 | Toronto FC | - | Charlotte FC | 4:0 |  |
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| 6. Round | 31/07/2022 | New England Revolution | - | Toronto FC | 0:0 | ||||
| 7. Round | 07/08/2022 | Nashville SC | - | Toronto FC | 3:4 | |
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| 7. Round | 14/08/2022 | Toronto FC | - | Portland Timbers | 3:1 | |
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| 7. Round | 18/08/2022 | Toronto FC | - | New England Revolution | 2:2 | |
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| 7. Round | 21/08/2022 | Inter Miami CF | - | Toronto FC | 2:1 | |
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| 7. Round | 28/08/2022 | Charlotte FC | - | Toronto FC | 0:2 | |
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| 7. Round | 01/09/2022 | Toronto FC | - | Los Angeles Galaxy | 2:2 | |
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| 8. Round | 05/09/2022 | Toronto FC | - | CF Montréal | 3:4 | |
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| 8. Round | 11/09/2022 | Atlanta United FC | - | Toronto FC | 4:2 | |
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| 8. Round | 18/09/2022 | Orlando City | - | Toronto FC | 4:0 | |
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| 9. Round | 01/10/2022 | Toronto FC | - | Inter Miami CF | 0:1 | ||||
| 9. Round | 09/10/2022 | Philadelphia Union | - | Toronto FC | 4:0 | |
Italy
