| 1. Round | 20/08/2017 | Montevideo Wanderers | - | Danubio | 1:3 | ||||
| 2. Round | 27/08/2017 | Danubio | - | Nacional | 1:1 | ||||
| 3. Round | 02/09/2017 | Fénix | - | Danubio | 0:1 | ||||
| 4. Round | 09/09/2017 | Danubio | - | Rampla Juniors | 1:1 | ||||
| 5. Round | 16/09/2017 | Defensor Sporting | - | Danubio | 1:0 | ||||
| 6. Round | 08/10/2017 | Danubio | - | Sud América | 1:0 | ||||
| 7. Round | 15/10/2017 | Juventud de Las Piedras | - | Danubio | 2:1 | ||||
| 8. Round | 05/11/2017 | CA Cerro | - | Danubio | 1:2 | ||||
| 9. Round | 08/11/2017 | Danubio | - | Plaza Colonia | 2:2 | ||||
| 10. Round | 11/11/2017 | River Plate | - | Danubio | 1:1 | ||||
| 11. Round | 16/11/2017 | Danubio | - | Peñarol | 0:2 | ||||
| 12. Round | 19/11/2017 | Racing | - | Danubio | 5:2 | ||||
| 13. Round | 23/11/2017 | Danubio | - | El Tanque Sisley | 2:2 |  |
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| 14. Round | 26/11/2017 | Liverpool | - | Danubio | 5:0 | ||||
| 15. Round | 03/12/2017 | Danubio | - | Boston River | 1:0 |
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