| 1. Round | 10/01/2021 | CF América | - | Atlético San Luis | 2:1 |  |
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| 2. Round | 16/01/2021 | Club Necaxa | - | Atlético San Luis | 1:0 | ||||
| 9. Round | 02/03/2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | ||||
| 10. Round | 06/03/2021 | Atlético San Luis | - | Deportivo Toluca | 0:0 | ||||
| 11. Round | 15/03/2021 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 12. Round | 20/03/2021 | Atlético San Luis | - | Pumas UNAM | 0:1 | ||||
| 13. Round | 04/04/2021 | CF Monterrey | - | Atlético San Luis | 2:0 | |
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| 14. Round | 10/04/2021 | FC Juárez | - | Atlético San Luis | 2:1 | ||||
| 15. Round | 17/04/2021 | Atlético San Luis | - | Puebla FC | 1:4 |
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