| 1. Round | 25/08/2012 | Defensor Sporting | - | Nacional | 2:2 | ||||
| 2. Round | 01/09/2012 | Montevideo Wanderers | - | Defensor Sporting | 0:4 | ||||
| 3. Round | 15/09/2012 | Defensor Sporting | - | Liverpool | 2:0 |  |
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| 4. Round | 23/09/2012 | Progreso | - | Defensor Sporting | 1:4 | ||||
| 5. Round | 30/09/2012 | Defensor Sporting | - | Juventud de Las Piedras | 1:1 | ||||
| 6. Round | 07/10/2012 | El Tanque Sisley | - | Defensor Sporting | 1:1 | ||||
| 7. Round | 14/10/2012 | Defensor Sporting | - | Racing | 1:0 | ||||
| 10. Round | 04/11/2012 | Peñarol | - | Defensor Sporting | 2:1 | |
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| 11. Round | 10/11/2012 | Fénix | - | Defensor Sporting | 1:3 | ||||
| 13. Round | 24/11/2012 | River Plate | - | Defensor Sporting | 1:1 | ||||
| 14. Round | 01/12/2012 | Defensor Sporting | - | Cerro Largo | 1:0 | |
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| 15. Round | 08/12/2012 | Defensor Sporting | - | CA Cerro | 2:0 | |
Uruguay