| 1. Round | 16/07/2021 | Independiente II | - | Argentinos Juniors II | 3:0 | ||||
| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 3. Round | 27/07/2021 | Arsenal de Sarandí II | - | Argentinos Juniors II | 3:1 | ||||
| 4. Round | 02/08/2021 | Argentinos Juniors II | - | Central Córdoba SdE II | 1:0 | ||||
| 5. Round | 06/08/2021 | Boca Juniors II | - | Argentinos Juniors II | 0:1 | ||||
| 7. Round | 20/08/2021 | San Lorenzo II | - | Argentinos Juniors II | 1:3 |  |
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| 8. Round | 26/08/2021 | Argentinos Juniors II | - | Talleres de Córdoba II | 0:1 | ||||
| 9. Round | 30/08/2021 | Unión de Santa Fe II | - | Argentinos Juniors II | 1:2 | ||||
| 10. Round | 03/09/2021 | Estudiantes II | - | Argentinos Juniors II | 2:0 | ||||
| 11. Round | 10/09/2021 | Argentinos Juniors II | - | Patronato de Paraná II | 3:0 | ||||
| 18. Round | 26/10/2021 | River Plate II | - | Argentinos Juniors II | 0:3 | ||||
| 19. Round | 01/11/2021 | Argentinos Juniors II | - | Lanús II | 2:1 | ||||
| 21. Round | 18/11/2021 | Argentinos Juniors II | - | Godoy Cruz II | 1:1 |
Spain