| 1. Round | 19/08/2017 | Boston River | - | Plaza Colonia | 3:0 |  |
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| 2. Round | 26/08/2017 | River Plate | - | Boston River | 1:1 | ||||
| 3. Round | 03/09/2017 | Boston River | - | Peñarol | 0:1 | ||||
| 4. Round | 12/09/2017 | Racing | - | Boston River | 1:1 |  |
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| 6. Round | 23/09/2017 | Liverpool | - | Boston River | 1:2 | ||||
| 12. Round | 19/11/2017 | Boston River | - | Defensor Sporting | 0:1 | ||||
| 13. Round | 22/11/2017 | Sud América | - | Boston River | 1:0 |  |
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| 14. Round | 25/11/2017 | Boston River | - | Juventud de Las Piedras | 3:1 | |
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| 15. Round | 03/12/2017 | Danubio | - | Boston River | 1:0 |
Uruguay
Spain