| 3. Round | 01/03/2022 | Santiago Wanderers | - | Santiago Morning | 2:2 |  |
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| 4. Round | 09/03/2022 | San Luis | - | Santiago Wanderers | 1:1 | ||||
| 6. Round | 22/03/2022 | Fernández Vial | - | Santiago Wanderers | 0:0 | ||||
| 7. Round | 03/04/2022 | Santiago Wanderers | - | CD Magallanes | 0:2 | ||||
| 1. Round | 05/06/2022 | Santiago Wanderers | - | Deportes Iquique | 2:0 | ||||
| 11. Round | 09/06/2022 | Santiago Wanderers | - | Unión San Felipe | 0:1 | ||||
| 18. Round | 02/07/2022 | Deportes Iquique | - | Santiago Wanderers | 2:1 | ||||
| 20. Round | 15/07/2022 | Santiago Morning | - | Santiago Wanderers | 1:2 | ||||
| 21. Round | 25/07/2022 | Santiago Wanderers | - | San Luis | 1:2 | ||||
| 22. Round | 02/08/2022 | Rangers | - | Santiago Wanderers | 1:2 | ||||
| 23. Round | 07/08/2022 | Santiago Wanderers | - | Fernández Vial | 2:2 | ||||
| 24. Round | 12/08/2022 | CD Magallanes | - | Santiago Wanderers | 0:1 | |
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| 19. Round | 16/08/2022 | Santiago Wanderers | - | Deportes Temuco | 3:0 | ||||
| 25. Round | 21/08/2022 | Santiago Wanderers | - | Deportes Copiapó | 1:0 | ||||
| 27. Round | 06/09/2022 | Santiago Wanderers | - | Deportes Melipilla | 2:2 |
Chile