| 1. Round | 25/07/2021 | RSC Anderlecht | - | Union Saint-Gilloise | 1:3 |  |
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| 2. Round | 01/08/2021 | Union Saint-Gilloise | - | Club Brugge KV | 0:1 | |
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| 3. Round | 07/08/2021 | K Beerschot VA | - | Union Saint-Gilloise | 0:3 | ||||
| 4. Round | 14/08/2021 | Union Saint-Gilloise | - | KV Kortrijk | 2:0 | ||||
| 5. Round | 22/08/2021 | KV Mechelen | - | Union Saint-Gilloise | 3:1 | ||||
| 7. Round | 12/09/2021 | KRC Genk | - | Union Saint-Gilloise | 1:1 | ||||
| 9. Round | 26/09/2021 | Union Saint-Gilloise | - | Royal Antwerp FC | 1:2 | ||||
| 10. Round | 02/10/2021 | Cercle Brugge | - | Union Saint-Gilloise | 0:3 | ||||
| 11. Round | 16/10/2021 | Union Saint-Gilloise | - | RFC Seraing | 4:2 | ||||
| 12. Round | 23/10/2021 | KAS Eupen | - | Union Saint-Gilloise | 2:3 | ||||
| 15. Round | 21/11/2021 | KV Oostende | - | Union Saint-Gilloise | 1:7 | ||||
| 16. Round | 26/11/2021 | Union Saint-Gilloise | - | Oud-Heverlee Leuven | 1:3 | ||||
| 17. Round | 03/12/2021 | Sint-Truidense VV | - | Union Saint-Gilloise | 1:2 | ||||
| 20. Round | 18/12/2021 | Union Saint-Gilloise | - | Cercle Brugge | 3:2 |
Uruguay
Italy