| 2. Round | 23/01/2010 | Estudiantes Tecos | - | Puebla FC | 2:3 | ||||
| 4. Round | 07/02/2010 | Atlante | - | Puebla FC | 1:1 | ||||
| 8. Round | 28/02/2010 | Puebla FC | - | Jaguares Chiapas | 3:3 | ||||
| 12. Round | 29/03/2010 | Puebla FC | - | CF América | 2:1 | ||||
| 13. Round | 04/04/2010 | Monarcas Morelia | - | Puebla FC | 1:1 | ||||
| 15. Round | 15/04/2010 | Atlas Guadalajara | - | Puebla FC | 0:2 |  |
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| 16. Round | 18/04/2010 | Puebla FC | - | Cruz Azul | 4:1 |  |
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| 17. Round | 25/04/2010 | Deportivo Toluca | - | Puebla FC | 2:1 | |
Mexico