| 1. Round | 25/07/2010 | Deportivo Guadalajara | - | Puebla FC | 0:0 | ||||
| 2. Round | 01/08/2010 | Puebla FC | - | Club San Luis | 2:1 |  |
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| 3. Round | 08/08/2010 | Estudiantes Tecos | - | Puebla FC | 1:3 | ||||
| 5. Round | 22/08/2010 | Pumas UNAM | - | Puebla FC | 4:1 | |
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| 6. Round | 29/08/2010 | Puebla FC | - | CF Pachuca | 3:1 | |
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| 7. Round | 11/09/2010 | Jaguares Chiapas | - | Puebla FC | 4:0 | |
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| 10. Round | 03/10/2010 | Puebla FC | - | Gallos Blancos (old) | 2:0 | ||||
| 11. Round | 09/10/2010 | Club Necaxa | - | Puebla FC | 1:0 | ||||
| 12. Round | 17/10/2010 | Puebla FC | - | CF América | 2:2 | ||||
| 13. Round | 24/10/2010 | Deportivo Toluca | - | Puebla FC | 2:1 | ||||
| 14. Round | 28/10/2010 | Puebla FC | - | Santos Laguna | 0:1 | |
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| 15. Round | 30/10/2010 | Cruz Azul | - | Puebla FC | 1:0 | ||||
| 16. Round | 07/11/2010 | Puebla FC | - | CF Monterrey | 2:0 |  |
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| 17. Round | 14/11/2010 | Monarcas Morelia | - | Puebla FC | 3:3 |  |
Mexico