1. Round | 11/09/2021 | River Plate | - | Cerrito | 1:0 | ||||
2. Round | 19/09/2021 | Liverpool | - | River Plate | 3:1 | ||||
3. Round | 25/09/2021 | River Plate | - | Deportivo Maldonado | 1:2 | ||||
4. Round | 02/10/2021 | River Plate | - | Cerro Largo | 0:4 | ||||
9. Round | 30/10/2021 | Boston River | - | River Plate | 1:2 |