| 1. Round | 12/02/2021 | Vélez Sarsfield II | - | Newell's Old Boys II | 3:0 | ||||
| 2. Round | 19/02/2021 | Newell's Old Boys II | - | Boca Juniors II | 1:3 | ||||
| 3. Round | 26/02/2021 | Talleres de Córdoba II | - | Newell's Old Boys II | 2:2 | ||||
| 4. Round | 05/03/2021 | Newell's Old Boys II | - | Independiente II | 1:2 | ||||
| 5. Round | 12/03/2021 | Defensa y Justicia II | - | Newell's Old Boys II | 2:1 | ||||
| 6. Round | 19/03/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 3:1 | ||||
| 7. Round | 26/03/2021 | Atlético Tucumán II | - | Newell's Old Boys II | 0:1 | ||||
| 8. Round | 02/04/2021 | Newell's Old Boys II | - | Huracán II | 3:0 | ||||
| 9. Round | 09/04/2021 | Lanús II | - | Newell's Old Boys II | 4:6 |  |
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| 10. Round | 16/04/2021 | Newell's Old Boys II | - | Patronato de Paraná II | 1:0 | ||||
| 11. Round | 23/04/2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 0:0 | ||||
| 13. Round | 07/05/2021 | Newell's Old Boys II | - | Sarmiento de Junín II | 6:2 |
Argentina