| 7. Round | 07/08/2022 | Colorado Rapids | - | Minnesota United FC | 4:3 | ||||
| 7. Round | 14/08/2022 | Colorado Rapids | - | Columbus Crew | 1:1 | ||||
| 7. Round | 18/08/2022 | Vancouver Whitecaps | - | Colorado Rapids | 2:1 | ||||
| 7. Round | 21/08/2022 | Colorado Rapids | - | Houston Dynamo | 1:1 |  |
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| 7. Round | 28/08/2022 | Philadelphia Union | - | Colorado Rapids | 6:0 | ||||
| 7. Round | 01/09/2022 | Nashville SC | - | Colorado Rapids | 4:1 | ||||
| 8. Round | 05/09/2022 | D.C. United | - | Colorado Rapids | 0:0 | ||||
| 8. Round | 11/09/2022 | Colorado Rapids | - | Vancouver Whitecaps | 3:1 | ||||
| 8. Round | 15/09/2022 | Colorado Rapids | - | San Jose Earthquakes | 2:1 | ||||
| 8. Round | 18/09/2022 | Los Angeles Galaxy | - | Colorado Rapids | 4:1 | |
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| 9. Round | 01/10/2022 | Colorado Rapids | - | FC Dallas | 1:0 | ||||
| 9. Round | 09/10/2022 | Austin FC | - | Colorado Rapids | 1:1 | |
Chile