| 3. Round | 28/01/2021 | Cancún FC | - | Atlético Morelia | 1:2 | ||||
| 4. Round | 04/02/2021 | TM Fútbol Club | - | Cancún FC | 1:1 | ||||
| 10. Round | 17/03/2021 | Venados FC | - | Cancún FC | 2:1 | ||||
| 12. Round | 28/03/2021 | Cancún FC | - | Tepatitlán | 5:1 | ||||
| 14. Round | 08/04/2021 | Cancún FC | - | Leones Negros | 2:0 | ||||
| 15. Round | 15/04/2021 | Pumas Tabasco | - | Cancún FC | 1:2 |  |
Mexico