| 2. Round | 28/08/2021 | VV Sint Bavo | - | Sportlust '46 | 3:0 |  |
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| 3. Round | 04/09/2021 | Excelsior '31 | - | VV Sint Bavo | 1:2 | ||||
| 4. Round | 11/09/2021 | VV Sint Bavo | - | VVOG Harderwijk | 1:1 | ||||
| 5. Round | 18/09/2021 | Sparta Nijkerk | - | VV Sint Bavo | 2:0 | ||||
| 8. Round | 09/10/2021 | VV Sint Bavo | - | ACV Assen | 0:3 | ||||
| 9. Round | 16/10/2021 | Harkemase Boys | - | VV Sint Bavo | 4:2 | ||||
| 10. Round | 30/10/2021 | VV Sint Bavo | - | VV DOVO Veenendaal | 0:3 | ||||
| 13. Round | 20/11/2021 | FC Lisse | - | VV Sint Bavo | 2:1 | ||||
| 14. Round | 27/11/2021 | VV Sint Bavo | - | ODIN '59 | 1:2 |
Netherlands