| 1. Round | 01/06/2021 | Albion | - | CA Cerro | 1:2 | ||||
| 2. Round | 09/06/2021 | Juventud de Las Piedras | - | Albion | 1:2 | ||||
| 3. Round | 16/06/2021 | Albion | - | Defensor Sporting | 2:2 | ||||
| 4. Round | 25/06/2021 | Uruguay Montevideo | - | Albion | 2:2 | ||||
| 5. Round | 30/06/2021 | Albion | - | Central Español | 1:2 | ||||
| 6. Round | 08/07/2021 | Rampla Juniors | - | Albion | 0:1 |  |
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| 7. Round | 15/07/2021 | Albion | - | Atenas | 1:0 | ||||
| 8. Round | 22/07/2021 | Danubio | - | Albion | 0:2 |  |
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| 9. Round | 29/07/2021 | Albion | - | Racing | 0:0 | |
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| 10. Round | 04/08/2021 | Rocha | - | Albion | 0:2 | |
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| 11. Round | 14/08/2021 | Albion | - | Villa Teresa | 2:0 | ||||
| 14. Round | 30/09/2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 15. Round | 04/10/2021 | Albion | - | Uruguay Montevideo | 1:0 | |
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| 16. Round | 11/10/2021 | Central Español | - | Albion | 3:4 | ||||
| 17. Round | 19/10/2021 | Albion | - | Rampla Juniors | 2:0 | |
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| 18. Round | 28/10/2021 | Atenas | - | Albion | 1:2 | ||||
| 19. Round | 01/11/2021 | Albion | - | Danubio | 2:1 | ||||
| 20. Round | 09/11/2021 | Racing | - | Albion | 1:1 | ||||
| 21. Round | 18/11/2021 | Albion | - | Rocha | 0:1 | ||||
| 22. Round | 24/11/2021 | Villa Teresa | - | Albion | 1:1 |
Uruguay