| 3. Round | 26/04/2021 | Puerto Montt | - | San Luis | 2:1 |  |
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| 4. Round | 03/05/2021 | San Luis | - | Unión San Felipe | 1:2 | |
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| 5. Round | 09/05/2021 | Deportes Iquique | - | San Luis | 0:0 | ||||
| 7. Round | 25/05/2021 | San Luis | - | Deportes Copiapó | 1:2 | ||||
| 8. Round | 30/05/2021 | Cobreloa | - | San Luis | 1:0 | ||||
| 9. Round | 07/06/2021 | San Luis | - | San Marcos | 0:1 | |
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| 10. Round | 11/07/2021 | Santa Cruz | - | San Luis | 2:0 | ||||
| 11. Round | 15/07/2021 | Santiago Morning | - | San Luis | 0:0 | |
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| 12. Round | 23/07/2021 | San Luis | - | Universidad de Concepción | 1:0 | |
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| 13. Round | 01/08/2021 | Coquimbo Unido | - | San Luis | 0:1 | ||||
| 15. Round | 17/08/2021 | Barnechea | - | San Luis | 0:0 | ||||
| 16. Round | 23/08/2021 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 17. Round | 28/08/2021 | Rangers | - | San Luis | 0:1 | ||||
| 18. Round | 01/09/2021 | San Luis | - | Puerto Montt | 0:1 |
Chile