| 3. Round | 03/03/2022 | Barnechea | - | San Luis | 3:1 | ||||
| 9. Round | 18/04/2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 10. Round | 21/04/2022 | Puerto Montt | - | San Luis | 1:1 | ||||
| 12. Round | 30/04/2022 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 13. Round | 07/05/2022 | Deportes Iquique | - | San Luis | 1:1 | ||||
| 14. Round | 13/05/2022 | San Luis | - | Fernández Vial | 0:0 |  |
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| 15. Round | 18/05/2022 | Santa Cruz | - | San Luis | 2:0 |  |
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| 22. Round | 01/08/2022 | Santiago Morning | - | San Luis | 1:0 | |
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| 24. Round | 16/08/2022 | Deportes Copiapó | - | San Luis | 1:1 | ||||
| 26. Round | 31/08/2022 | Deportes Melipilla | - | San Luis | 1:2 | ||||
| 30. Round | 04/10/2022 | San Luis | - | Deportes Iquique | 0:0 | ||||
| 31. Round | 10/10/2022 | Fernández Vial | - | San Luis | 1:1 | ||||
| 33. Round | 24/10/2022 | San Luis | - | Recoleta | 2:1 | ||||
| 34. Round | 01/11/2022 | Universidad de Concepción | - | San Luis | 3:1 |
Chile