| 5. Round | 18/08/2018 | Club Necaxa [U20] | - | Puebla FC [U20] | 0:0 |  |
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| 6. Round | 21/08/2018 | Puebla FC [U20] | - | Atlas Guadalajara [U20] | 1:2 | ||||
| 7. Round | 25/08/2018 | CF Pachuca [U20] | - | Puebla FC [U20] | 3:2 | ||||
| 8. Round | 31/08/2018 | Puebla FC [U20] | - | CF Monterrey [U20] | 1:1 |  |
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| 9. Round | 15/09/2018 | Gallos Blancos [U20] | - | Puebla FC [U20] | 3:0 | ||||
| 10. Round | 21/09/2018 | Puebla FC [U20] | - | CF América [U20] | 0:1 | ||||
| 11. Round | 30/09/2018 | Pumas UNAM [U20] | - | Puebla FC [U20] | 2:0 | ||||
| 12. Round | 07/10/2018 | Puebla FC [U20] | - | Lobos BUAP [U20] | 3:2 |  |
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| 13. Round | 21/10/2018 | Monarcas Morelia [U20] | - | Puebla FC [U20] | 1:0 | ||||
| 14. Round | 28/10/2018 | Club León [U20] | - | Puebla FC [U20] | 4:1 | ||||
| 15. Round | 02/11/2018 | Puebla FC [U20] | - | Deportivo Guadalajara [U20] | 1:1 | ||||
| 16. Round | 10/11/2018 | UANL Tigres [U20] | - | Puebla FC [U20] | 1:2 | ||||
| 17. Round | 23/11/2018 | Puebla FC [U20] | - | Club Tijuana [U20] | 0:0 |
Mexico