| 9. Round | 05/03/2016 | River Plate | - | Club Rubio Ñu | 1:4 |  |
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| 10. Round | 11/03/2016 | General Díaz | - | River Plate | 3:0 | ||||
| 11. Round | 21/03/2016 | River Plate | - | Club Olimpia | 0:3 | ||||
| 12. Round | 31/03/2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 18. Round | 30/04/2016 | Guaraní | - | River Plate | 4:2 | ||||
| 19. Round | 06/05/2016 | River Plate | - | Deportivo Capiatá | 1:1 | ||||
| 20. Round | 08/05/2016 | Club Rubio Ñu | - | River Plate | 1:2 |
Paraguay