| 1. Round | 09/07/2016 | Libertad | - | River Plate | 1:1 | ||||
| 7. Round | 12/08/2016 | Sportivo Luqueño | - | River Plate | 1:0 | ||||
| 8. Round | 19/08/2016 | Deportivo Capiatá | - | River Plate | 0:3 | ||||
| 9. Round | 29/08/2016 | River Plate | - | Cerro Porteño | 2:3 |  |
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| 10. Round | 10/09/2016 | Sol de América | - | River Plate | 2:6 | ||||
| 11. Round | 18/09/2016 | River Plate | - | Club Nacional | 2:3 | ||||
| 12. Round | 24/09/2016 | River Plate | - | Libertad | 2:0 |  |
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| 20. Round | 02/12/2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 21. Round | 10/12/2016 | River Plate | - | Sol de América | 2:4 |
Paraguay