| 6. Round | 16/02/2019 | River Plate | - | Libertad | 1:1 | ||||
| 7. Round | 23/02/2019 | Deportivo Capiatá | - | River Plate | 3:3 | ||||
| 8. Round | 26/02/2019 | River Plate | - | General Díaz | 3:2 | ||||
| 10. Round | 09/03/2019 | Club Olimpia | - | River Plate | 0:0 | ||||
| 11. Round | 16/03/2019 | River Plate | - | Club Nacional | 1:1 | ||||
| 13. Round | 01/04/2019 | Sportivo Luqueño | - | River Plate | 3:1 | ||||
| 16. Round | 14/04/2019 | River Plate | - | Cerro Porteño | 1:5 |  |
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| 17. Round | 21/04/2019 | Libertad | - | River Plate | 2:1 | ||||
| 22. Round | 19/05/2019 | Club Nacional | - | River Plate | 0:0 |
Paraguay