| 1. Round | 15/07/2022 | Resistencia SC | - | Sol de América | 2:1 |  |
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| 2. Round | 21/07/2022 | Club Nacional | - | Resistencia SC | 1:1 |  |
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| 5. Round | 05/08/2022 | Resistencia SC | - | Guaireña FC | 1:2 | ||||
| 6. Round | 15/08/2022 | Tacuary | - | Resistencia SC | 1:1 | ||||
| 7. Round | 19/08/2022 | Resistencia SC | - | Sportivo Ameliano | 2:1 | |
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| 8. Round | 27/08/2022 | Club Olimpia | - | Resistencia SC | 1:1 | ||||
| 9. Round | 03/09/2022 | Resistencia SC | - | General Caballero DJLM | 0:0 | ||||
| 10. Round | 10/09/2022 | Resistencia SC | - | Cerro Porteño | 0:2 | ||||
| 11. Round | 16/09/2022 | 12 de Octubre de Itauguá | - | Resistencia SC | 1:0 | ||||
| 12. Round | 20/09/2022 | Sol de América | - | Resistencia SC | 0:1 | ||||
| 13. Round | 25/09/2022 | Resistencia SC | - | Club Nacional | 0:1 | ||||
| 17. Round | 15/10/2022 | Resistencia SC | - | Tacuary | 0:3 | |
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| 21. Round | 07/11/2022 | Cerro Porteño | - | Resistencia SC | 1:0 | ||||
| 22. Round | 13/11/2022 | Resistencia SC | - | 12 de Octubre de Itauguá | 0:0 |
Paraguay