| 1. Round | 13/01/2021 | Club Celaya | - | Tepatitlán | 1:1 | ||||
| 2. Round | 21/01/2021 | Club Celaya | - | Pumas Tabasco | 2:1 | ||||
| 3. Round | 27/01/2021 | Cimarrones de Sonora | - | Club Celaya | 2:2 |  |
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| 4. Round | 04/02/2021 | Club Celaya | - | Mineros de Zacatecas | 2:0 | ||||
| 5. Round | 15/02/2021 | Atlante | - | Club Celaya | 0:0 | ||||
| 6. Round | 17/02/2021 | Club Celaya | - | Cancún FC | 4:0 | ||||
| 7. Round | 28/02/2021 | Atlético Morelia | - | Club Celaya | 0:2 | |
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| 8. Round | 05/03/2021 | Club Celaya | - | Coyotes de Tlaxcala | 0:0 | ||||
| 9. Round | 11/03/2021 | TM Fútbol Club | - | Club Celaya | 1:0 | |
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| 10. Round | 17/03/2021 | Club Celaya | - | Dorados de Sinaloa | 2:2 | ||||
| 11. Round | 24/03/2021 | Venados FC | - | Club Celaya | 0:1 | ||||
| 12. Round | 27/03/2021 | Club Celaya | - | Alebrijes de Oaxaca | 0:0 | |
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| 13. Round | 02/04/2021 | Leones Negros | - | Club Celaya | 3:1 | ||||
| 14. Round | 07/04/2021 | Correcaminos UAT | - | Club Celaya | 1:2 | ||||
| 15. Round | 16/04/2021 | Club Celaya | - | Tapatío | 0:0 |
Mexico