| 1. Round | 31/07/2016 | Club Deportivo River Plate Ecuador | - | Independiente del Valle | 3:0 |  |
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| 2. Round | 06/08/2016 | Delfín SC | - | Club Deportivo River Plate Ecuador | 0:0 | ||||
| 3. Round | 13/08/2016 | Club Deportivo River Plate Ecuador | - | LDU Quito | 0:1 | ||||
| 4. Round | 20/08/2016 | Deportivo Cuenca | - | Club Deportivo River Plate Ecuador | 3:0 | ||||
| 5. Round | 27/08/2016 | Club Deportivo River Plate Ecuador | - | Aucas | 1:0 | ||||
| 6. Round | 04/09/2016 | El Nacional | - | Club Deportivo River Plate Ecuador | 2:1 | |
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| 7. Round | 10/09/2016 | Club Deportivo River Plate Ecuador | - | Mushuc Runa | 0:0 | ||||
| 8. Round | 17/09/2016 | Club Deportivo River Plate Ecuador | - | Barcelona | 0:1 | ||||
| 15. Round | 23/10/2016 | Barcelona | - | Club Deportivo River Plate Ecuador | 1:0 | ||||
| 16. Round | 30/10/2016 | Mushuc Runa | - | Club Deportivo River Plate Ecuador | 0:2 | |
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| 17. Round | 04/11/2016 | Club Deportivo River Plate Ecuador | - | El Nacional | 1:2 | ||||
| 20. Round | 26/11/2016 | LDU Quito | - | Club Deportivo River Plate Ecuador | 1:0 | ||||
| 21. Round | 04/12/2016 | Club Deportivo River Plate Ecuador | - | Delfín SC | 0:1 |
Uruguay