| 1. Round | 21/07/2018 | Atlético San Luis | - | Mineros de Zacatecas | 0:0 | ||||
| 2. Round | 28/07/2018 | TM Fútbol Club | - | Atlético San Luis | 1:2 | ||||
| 3. Round | 04/08/2018 | Atlético San Luis | - | Venados FC | 1:0 | ||||
| 4. Round | 11/08/2018 | Atlético San Luis | - | Atlético Zacatepec | 0:0 | ||||
| 5. Round | 19/08/2018 | Club Celaya | - | Atlético San Luis | 0:4 | ||||
| 7. Round | 02/09/2018 | FC Juárez | - | Atlético San Luis | 1:0 | ||||
| 14. Round | 03/11/2018 | Atlético San Luis | - | Leones Negros | 0:0 | ||||
| 15. Round | 11/11/2018 | Dorados de Sinaloa | - | Atlético San Luis | 1:1 |
Mexico