| 2. Round | 26/09/2021 | Yalmakan FC | - | Lobos ULMX | 1:0 | ||||
| 3. Round | 03/10/2021 | Reboceros de La Piedad | - | Yalmakan FC | 1:2 | ||||
| 4. Round | 10/10/2021 | Yalmakan FC | - | Deportivo Dongu | 0:1 | ||||
| 5. Round | 13/10/2021 | Cañoneros FC | - | Yalmakan FC | 0:1 | ||||
| 7. Round | 23/10/2021 | Escorpiones | - | Yalmakan FC | 0:1 | ||||
| 8. Round | 31/10/2021 | Yalmakan FC | - | Cafetaleros de Chiapas | 0:3 |  |
|||
| 9. Round | 05/11/2021 | CD Zap | - | Yalmakan FC | 1:3 | |
|||
| 10. Round | 10/11/2021 | Yalmakan FC | - | Inter de Querétaro | 1:0 | ||||
| 11. Round | 14/11/2021 | Montañeses FC | - | Yalmakan FC | 3:0 | ||||
| 12. Round | 21/11/2021 | Yalmakan FC | - | Leviatán FC | 10:0 | ||||
| 13. Round | 27/11/2021 | Sporting Canamy | - | Yalmakan FC | 0:3 |  |
Mexico