| 2. Round | 16/01/2022 | CF Pachuca | - | Deportivo Guadalajara | 2:1 | ||||
| 3. Round | 23/01/2022 | Club León | - | CF Pachuca | 2:1 | ||||
| 4. Round | 05/02/2022 | Club Necaxa | - | CF Pachuca | 1:3 | ||||
| 7. Round | 25/02/2022 | CF Pachuca | - | Mazatlán FC | 3:1 | ||||
| 8. Round | 03/03/2022 | Atlas Guadalajara | - | CF Pachuca | 0:1 | ||||
| 10. Round | 13/03/2022 | Deportivo Toluca | - | CF Pachuca | 0:3 | ||||
| 11. Round | 20/03/2022 | CF Pachuca | - | Cruz Azul | 1:0 | ||||
| 12. Round | 04/04/2022 | Santos Laguna | - | CF Pachuca | 3:1 | ||||
| 13. Round | 12/04/2022 | CF Pachuca | - | Club Tijuana | 0:0 |  |
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| 14. Round | 16/04/2022 | FC Juárez | - | CF Pachuca | 1:2 | ||||
| 16. Round | 23/04/2022 | CF Pachuca | - | CF Monterrey | 3:0 | ||||
| 17. Round | 01/05/2022 | Pumas UNAM | - | CF Pachuca | 2:0 |
Mexico