| 2. Round | 31/07/2021 | UANL Tigres [U16] | - | Club León [U16] | 3:1 | ||||
| 8. Round | 11/09/2021 | Club León [U16] | - | Atlas Guadalajara [U16] | 2:1 | ||||
| 9. Round | 19/09/2021 | Mazatlán FC [U16] | - | Club León [U16] | 0:4 | ||||
| 13. Round | 16/10/2021 | Club León [U16] | - | Mazatlán FC [U16] | 4:1 | ||||
| 14. Round | 23/10/2021 | Atlas Guadalajara [U16] | - | Club León [U16] | 0:0 | ||||
| 15. Round | 30/10/2021 | Club León [U16] | - | Atlético San Luis [U16] | 2:1 | ||||
| 16. Round | 06/11/2021 | Club Necaxa [U16] | - | Club León [U16] | 0:1 | ||||
| 17. Round | 13/11/2021 | CF Monterrey [U16] | - | Club León [U16] | 0:3 | ||||
| 18. Round | 20/11/2021 | Club León [U16] | - | Santos Laguna [U16] | 0:1 |
Mexico