| 1. Round | 06/01/2022 | Alebrijes de Oaxaca | - | Cancún FC | 2:0 | ||||
| 2. Round | 12/01/2022 | TM Fútbol Club | - | Alebrijes de Oaxaca | 1:1 |  |
|||
| 4. Round | 26/01/2022 | CF Monterrey II | - | Alebrijes de Oaxaca | 2:0 | ||||
| 5. Round | 29/01/2022 | Alebrijes de Oaxaca | - | Atlético Morelia | 1:1 | ||||
| 8. Round | 17/02/2022 | Cimarrones de Sonora | - | Alebrijes de Oaxaca | 0:1 |
Mexico