1. Round | 24/01/2016 | River Plate | - | Cerro Porteño | 0:2 | ||||
2. Round | 29/01/2016 | Sol de América | - | River Plate | 0:1 | ||||
3. Round | 03/02/2016 | River Plate | - | Sportivo Luqueño | 0:1 | ||||
4. Round | 08/02/2016 | Libertad | - | River Plate | 3:1 | ||||
5. Round | 13/02/2016 | River Plate | - | General Caballero ZC | 0:0 | ||||
6. Round | 20/02/2016 | Club Nacional | - | River Plate | 0:0 | ||||
7. Round | 27/02/2016 | River Plate | - | Guaraní | 1:1 | ||||
9. Round | 05/03/2016 | River Plate | - | Club Rubio Ñu | 1:4 | ||||
10. Round | 11/03/2016 | General Díaz | - | River Plate | 3:0 | ||||
12. Round | 31/03/2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
16. Round | 21/04/2016 | General Caballero ZC | - | River Plate | 2:3 | ||||
17. Round | 25/04/2016 | River Plate | - | Club Nacional | 1:3 | ||||
18. Round | 30/04/2016 | Guaraní | - | River Plate | 4:2 | ||||
19. Round | 06/05/2016 | River Plate | - | Deportivo Capiatá | 1:1 |