1. Round | 24/07/2021 | MFK Ružomberok | - | FK Senica | 0:0 | ||||
4. Round | 14/08/2021 | FK Senica | - | FC DAC 1904 | 1:1 | ||||
5. Round | 22/08/2021 | MŠK Žilina | - | FK Senica | 3:0 | ||||
8. Round | 18/09/2021 | AS Trenčín | - | FK Senica | 3:3 | ||||
10. Round | 02/10/2021 | ŠKF Sereď | - | FK Senica | 2:1 | ||||
12. Round | 23/10/2021 | FK Senica | - | MFK Ružomberok | 0:2 | ||||
18. Round | 11/12/2021 | FK Pohronie | - | FK Senica | 0:1 | ||||
19. Round | 18/12/2021 | FK Senica | - | AS Trenčín | 1:0 |