| 9. Round | 08/10/2017 | 1. FC Kaan-Marienborn | - | FC Schalke 04 II | 1:0 | ||||
| 10. Round | 15/10/2017 | FC Schalke 04 II | - | Sportfreunde Siegen | 4:0 | ||||
| 12. Round | 29/10/2017 | FC Schalke 04 II | - | FC Brünninghausen | 3:0 | ||||
| 13. Round | 05/11/2017 | FC Schalke 04 II | - | Westfalia Herne | 0:2 | ||||
| 20. Round | 25/02/2018 | FC Schalke 04 II | - | Hammer SpVg | 0:1 | ||||
| 21. Round | 04/03/2018 | FC Schalke 04 II | - | FCE Rheine | 4:1 | ||||
| 23. Round | 18/03/2018 | TuS Haltern | - | FC Schalke 04 II | 1:0 |  |
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| 24. Round | 25/03/2018 | FC Schalke 04 II | - | Arminia Bielefeld II | 4:0 | ||||
| 25. Round | 29/03/2018 | FC Gütersloh | - | FC Schalke 04 II | 2:2 | ||||
| 16. Round | 18/04/2018 | TuS Ennepetal | - | FC Schalke 04 II | 4:0 | ||||
| 17. Round | 02/05/2018 | FC Schalke 04 II | - | TSG Sprockhövel | 2:0 | ||||
| 33. Round | 21/05/2018 | FC Schalke 04 II | - | TuS Ennepetal | 6:0 | ||||
| 34. Round | 27/05/2018 | TSG Sprockhövel | - | FC Schalke 04 II | 2:2 |
Austria