| 1. Round | 24/07/2021 | Tatran Liptovský Mikuláš | - | Slovan Bratislava | 1:4 |  |
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| 2. Round | 31/07/2021 | Slovan Bratislava | - | AS Trenčín | 2:0 | ||||
| 4. Round | 14/08/2021 | Slovan Bratislava | - | MFK Zemplín Michalovce | 3:1 | ||||
| 5. Round | 22/08/2021 | ŠKF Sereď | - | Slovan Bratislava | 0:1 | ||||
| 6. Round | 29/08/2021 | Slovan Bratislava | - | Zlaté Moravce | 4:1 | ||||
| 7. Round | 12/09/2021 | FC DAC 1904 | - | Slovan Bratislava | 1:1 | ||||
| 3. Round | 22/09/2021 | MFK Ružomberok | - | Slovan Bratislava | 1:0 | ||||
| 9. Round | 25/09/2021 | FK Senica | - | Slovan Bratislava | 0:3 | ||||
| 12. Round | 24/10/2021 | Slovan Bratislava | - | Tatran Liptovský Mikuláš | 4:0 | ||||
| 14. Round | 07/11/2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 | ||||
| 16. Round | 29/11/2021 | Slovan Bratislava | - | ŠKF Sereď | 2:0 | ||||
| 17. Round | 03/12/2021 | Zlaté Moravce | - | Slovan Bratislava | 1:2 |
Slovakia