| 11. Round | 22/10/2017 | Rot Weiss Ahlen | - | FC Schalke 04 II | 0:1 |  |
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| 19. Round | 18/02/2018 | SV Lippstadt 08 | - | FC Schalke 04 II | 1:0 | ||||
| 20. Round | 25/02/2018 | FC Schalke 04 II | - | Hammer SpVg | 0:1 | ||||
| 23. Round | 18/03/2018 | TuS Haltern | - | FC Schalke 04 II | 1:0 | ||||
| 24. Round | 25/03/2018 | FC Schalke 04 II | - | Arminia Bielefeld II | 4:0 | ||||
| 25. Round | 29/03/2018 | FC Gütersloh | - | FC Schalke 04 II | 2:2 | ||||
| 26. Round | 02/04/2018 | FC Schalke 04 II | - | 1. FC Kaan-Marienborn | 2:0 | |
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| 27. Round | 08/04/2018 | Sportfreunde Siegen | - | FC Schalke 04 II | 0:2 | ||||
| 28. Round | 14/04/2018 | FC Schalke 04 II | - | Rot Weiss Ahlen | 2:0 | ||||
| 16. Round | 18/04/2018 | TuS Ennepetal | - | FC Schalke 04 II | 4:0 | ||||
| 29. Round | 22/04/2018 | FC Brünninghausen | - | FC Schalke 04 II | 0:3 | ||||
| 30. Round | 28/04/2018 | Westfalia Herne | - | FC Schalke 04 II | 0:1 | ||||
| 17. Round | 02/05/2018 | FC Schalke 04 II | - | TSG Sprockhövel | 2:0 | ||||
| 32. Round | 13/05/2018 | ASC 09 Dortmund | - | FC Schalke 04 II | 0:1 | ||||
| 33. Round | 21/05/2018 | FC Schalke 04 II | - | TuS Ennepetal | 6:0 | ||||
| 34. Round | 27/05/2018 | TSG Sprockhövel | - | FC Schalke 04 II | 2:2 |
Germany