| 10. Round | 25/09/1980 | VfL Osnabrück | - | Fortuna Köln | 3:1 | ||||
| 11. Round | 30/09/1980 | Fortuna Köln | - | Rot-Weiß Oberhausen | 2:2 | ||||
| 12. Round | 07/10/1980 | 1. FC Bocholt | - | Fortuna Köln | 1:1 |  |
|||
| 13. Round | 11/10/1980 | Fortuna Köln | - | TeBe Berlin | 2:2 | ||||
| 14. Round | 18/10/1980 | VfB Oldenburg | - | Fortuna Köln | 5:0 | ||||
| 15. Round | 25/10/1980 | Fortuna Köln | - | SC Viktoria 04 Köln | 3:2 | ||||
| 17. Round | 07/11/1980 | Alemannia Aachen | - | Fortuna Köln | 1:1 | ||||
| 18. Round | 14/11/1980 | Fortuna Köln | - | Eintracht Braunschweig | 5:2 | ||||
| 19. Round | 28/11/1980 | OSV Hannover | - | Fortuna Köln | 1:0 | ||||
| 21. Round | 12/12/1980 | SpVgg Erkenschwick | - | Fortuna Köln | 0:4 | |
|||
| 23. Round | 09/01/1981 | Fortuna Köln | - | Preußen Münster | 3:0 | ||||
| 28. Round | 20/02/1981 | Rot-Weiß Lüdenscheid | - | Fortuna Köln | 1:0 | ||||
| 29. Round | 06/03/1981 | Fortuna Köln | - | Hannover 96 | 3:0 |
Denmark