| 11. Round | 06/11/2020 | FC Den Bosch | - | Jong PSV | 1:2 |  |
|||
| 13. Round | 20/11/2020 | MVV | - | Jong PSV | 3:3 | ||||
| 12. Round | 24/11/2020 | Jong PSV | - | FC Utrecht (J) | 1:1 | ||||
| 14. Round | 27/11/2020 | Helmond Sport | - | Jong PSV | 1:0 | ||||
| 10. Round | 30/11/2020 | Jong PSV | - | SC Cambuur | 0:1 | ||||
| 16. Round | 11/12/2020 | TOP Oss | - | Jong PSV | 3:2 | |
|||
| 17. Round | 21/12/2020 | Jong PSV | - | Almere City FC | 1:2 | |
|||
| 21. Round | 22/01/2021 | SC Cambuur | - | Jong PSV | 5:1 | ||||
| 22. Round | 29/01/2021 | Jong PSV | - | Jong Ajax | 1:2 |  |
|||
| 23. Round | 05/02/2021 | Roda JC Kerkrade | - | Jong PSV | 5:1 | |
|||
| 25. Round | 19/02/2021 | Jong PSV | - | FC Den Bosch | 1:0 | ||||
| 24. Round | 23/02/2021 | Jong PSV | - | Helmond Sport | 2:2 | |
|||
| 26. Round | 26/02/2021 | Go Ahead Eagles | - | Jong PSV | 1:0 | ||||
| 27. Round | 09/03/2021 | Jong PSV | - | FC Dordrecht | 0:1 | ||||
| 28. Round | 12/03/2021 | NEC Nijmegen | - | Jong PSV | 2:0 | ||||
| 30. Round | 15/03/2021 | FC Utrecht (J) | - | Jong PSV | 1:6 | |
|||
| 29. Round | 19/03/2021 | Jong PSV | - | AZ Alkmaar (J) | 3:0 | |
|||
| 31. Round | 02/04/2021 | SBV Excelsior | - | Jong PSV | 0:0 | ||||
| 32. Round | 05/04/2021 | Jong PSV | - | MVV | 3:1 | ||||
| 33. Round | 09/04/2021 | FC Eindhoven | - | Jong PSV | 0:2 |
Netherlands
Guinea