| 16. Round | 12/02/2022 | NK Varaždin | - | HNK Orijent Rijeka | 2:1 | ||||
| 17. Round | 19/02/2022 | NK Varaždin | - | HNK Cibalia | 1:0 | ||||
| 18. Round | 26/02/2022 | NK Varaždin | - | NK Inter Zaprešić | 0:1 |  |
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| 20. Round | 12/03/2022 | NK Varaždin | - | NK BSK Bijelo Brdo | 3:0 |  |
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| 21. Round | 20/03/2022 | Dinamo Zagreb II | - | NK Varaždin | 1:0 | ||||
| 22. Round | 02/04/2022 | NK Varaždin | - | NK Solin | 1:0 | ||||
| 23. Round | 10/04/2022 | NK Croatia Zmijavci | - | NK Varaždin | 0:1 | ||||
| 24. Round | 16/04/2022 | NK Varaždin | - | NK Opatija | 4:0 | |
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| 25. Round | 23/04/2022 | NK Varaždin | - | NK Osijek II | 4:1 | ||||
| 26. Round | 30/04/2022 | NK Rudeš | - | NK Varaždin | 3:0 | ||||
| 27. Round | 07/05/2022 | NK Varaždin | - | NK Jarun | 4:0 | ||||
| 28. Round | 13/05/2022 | NK Sesvete | - | NK Varaždin | 2:3 | |
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| 29. Round | 22/05/2022 | NK Varaždin | - | NK Dugopolje | 2:1 | |
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| 30. Round | 28/05/2022 | NK Dubrava | - | NK Varaždin | 2:3 | |
Croatia