| 2. Round | 15/05/2021 | Birmingham Legion | - | Memphis 901 | 1:0 | ||||
| 2. Round | 23/05/2021 | Atlanta United II | - | Memphis 901 | 2:2 |  |
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| 2. Round | 30/05/2021 | OKC Energy FC | - | Memphis 901 | 0:0 | ||||
| 3. Round | 06/06/2021 | Indy Eleven | - | Memphis 901 | 1:2 | |
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| 3. Round | 13/06/2021 | Louisville City FC | - | Memphis 901 | 3:0 | ||||
| 3. Round | 17/06/2021 | Memphis 901 | - | Atlanta United II | 1:0 | ||||
| 3. Round | 20/06/2021 | Memphis 901 | - | OKC Energy FC | 0:1 | ||||
| 3. Round | 27/06/2021 | Memphis 901 | - | Sporting Kansas City 2 | 2:3 | ||||
| 4. Round | 04/07/2021 | Atlanta United II | - | Memphis 901 | 2:2 | ||||
| 4. Round | 18/07/2021 | Indy Eleven | - | Memphis 901 | 1:1 | ||||
| 4. Round | 25/07/2021 | Memphis 901 | - | FC Tulsa | 1:0 | ||||
| 5. Round | 01/08/2021 | Sporting Kansas City 2 | - | Memphis 901 | 1:2 | ||||
| 5. Round | 08/08/2021 | OKC Energy FC | - | Memphis 901 | 4:1 | ||||
| 5. Round | 11/08/2021 | Memphis 901 | - | Colorado Springs Switchbacks | 1:1 | |
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| 5. Round | 15/08/2021 | Memphis 901 | - | Birmingham Legion | 1:1 | ||||
| 5. Round | 26/08/2021 | FC Tulsa | - | Memphis 901 | 2:1 | ||||
| 5. Round | 29/08/2021 | Sporting Kansas City 2 | - | Memphis 901 | 0:0 | ||||
| 6. Round | 12/09/2021 | Memphis 901 | - | Miami FC | 0:2 |
Ghana